DMT acts on the HTR2A and HTR2C receptors. When you activate HTR2C receptors at high levels the nerves respond by changing the number HTR2C receptors. This is called having an "effect of receptor density".
You can read about it in this study: (I know what you are going to say, that this proves one cannot get habituated to DMT But that is wrong adn you will need to read the second study to understand why.
Because drug efficacy changes with receptor density and cellular microenvironment, we also examined the properties of DMT in native preparations using a behavioral and biochemical approach."
One difference was evident in that the 5-HT2C, but not the 5-HT2A, receptor showed a profound desensitization to DMT over time. This difference is interesting in light of the recent report that the hallucinogenic activity of DMT does not tolerate in humans and suggests the 5-HT2C receptor plays a less prominent role in the action of DMT.
Furthermore, abnormal receptor density ratios are strongly associated with positive and negative symptom severity, which are typically assessed using the Scale for the Assessment of Negative Symptoms
In addition, Hurlemann et al. (2007) proposed that 5-HT2A receptor density was also decreased in the At-Risk Mental State patient subgroup, regardless of conversion to psychosis [4]. The progressive decline in subcortical 5-HT2A receptor density could provide an indicator of conversion to schizophrenia.
Genocide is hyperbole, a true genocide would be enough to turn public opinion against the war, there are millions of Ukrainians living throughout Russia and millions of Russians living in Ukraine
