Another complication with RA and AS will be the number of linked autoantigens involved. Both RA and AS likely will benefit from collagen II autoantigens but also appear to be triggered by a bunch of other autoantigens as well. Still mRNA should cope with that case better than current methods too! It’s easy to print lots of different antigens in one go.

See https://pubmed.ncbi.nlm.nih.gov/12678429/