That's what antivirus is, essentially; it doesn't replace real security, but it can help.
I'm glad to see Apple realizes that it should be part of the OS, not a choice between bloated third-party poorly-integrated expensive trialware applications, as is the ridiculous status quo elsewhere.
I am on OSX and a few months ago I installed Sophos which is free for Mac (Personal use). I installed it specifically because (a) it was quiet. Set it and forget it. (b) it didn't take up many resource - Activity Monitor is showing 15MB RAM and 0.0 CPU usage) and third it was free.
I know Sophos from Windows - it is good software. ($45 bucks for Windows)
Sorry - I realize this looks like spam. I don't have a HN account and this is my first post. I assure you, in light of the malware conversation, I felt this was a good post to share as most Mac user (like me) don't have and don't need anti-virus software, but Sophos was a good option for me.
The thing to bear in mind is that a lot of 'Mac Antivirus' software has overwhelmingly consisted of signatures to stop you passing on Windows malware, rather than necessarily much that will protect your system.
EDIT: Just to be clear, I'm not saying this was necessarily negligent. I'm saying that time will tell how good any of these packages really are - assuming of course that Mac starts to get real malware rather than what I'll call trickware. That prediction has come and gone with little to show for it in the past, but it may not last.