One thing i miss in languages like python that don't enclose blocks in {} is the convenience of using % to find the matching beginning/end of the block.
That, and the lack of constant constants (class workarounds don't do it for me) are the only two "complaints" for me.
On the whole I really like significant white space (despite my suspicions before taking up the language). With a brace-blocked language like C, indentation can fool you into thinking there's a block when there really isn't.
This is very unlikely to happen in Python. A section of code that looks like a block due to indentation is virtually certain to be a single coherent block. I love that.
In my years of experience, I've found that huge ass blocks of code where % is useful in finding the beginning/end of a block are usually in need of massive amounts of refactoring.