It took a friend and I 2 days last year to build a compatibility layer that allowed to run all the tests of Deno on Node.

How far along is the story of cross compilation for the two ecosystems?

Node -> Deno: https://esm.sh

Deno -> Node: https://github.com/denoland/dnt

I had no joy trying to get a node JIRA library to run under deno with the various platforms. So still some way to go. Didn't seem far off. IIRC axios was the problem.