Haven't used winetricks in what feels like 10+ years, but as I recall it only dealt with a single wine prefix (~/.wine most likely). Bottles are namespaced prefixes (usually one for each application installed this way).

I don't know in practice how much that is needed in wine in order to avoid one "trick" interfering with another "trick" for another app. However, makes it easier to remove the extra cruft of uninstalled applications (like the dozen variants of the .net runtime, or whatever else it was that you had to install ad-nauseum in the past for some windows apps/games).