Prolonged sitting deconditions the gluteal muscles, and other muscles often compensate, which can overload them and alter hip/pelvic control. When tissues are strained, the body initiates repair via inflammation—a normal phase of healing. Routine NSAID use can blunt aspects of musculoskeletal healing in some contexts, so it’s worth using judiciously and with clinical guidance. With reduced movement, fascia can lose glide and become stiffer, limiting mobility. Over years, chronic abnormal loading may contribute to osteophytes (joint margins) or enthesophytes (at tendon/ligament insertions). Targeted strengthening, mobility work, and load management from a PT typically help.