It's hinted at in the article, but I wonder how much overwork and lack of sleep contribute to failures between cofounders, and overall failures. Both accentuate irritability and bad decision making. There's a lot of NASA work surrounding the psychology and performance of astronauts in a spaceship for long space trips, I would think that similar dynamics apply in the bubble of getting a startup up and running. NASA works their astronauts as hard as possible, but to optimize overall productivity, they also make sure they get rest and sleep.