In time spans like a decade, what people will think of as most important will be freedom issues (democratic and anti-democratic movements around the world, individual privacy concerns, efforts by religious groups to enforce their preferred societal norms).

In the longer run, the issues that threaten humanity as a whole, rather than as individuals, are as important. Things like: (1) Water/energy availability, both singly and combined. (2) Global climate change. (3) Local environmental quality (air, water, food). Of course, all of these are linked, but when working on solutions it still makes sense to think about them individually.