In Europe, it would be very rare for someone to drive for that long. They would take a train or plane.

Anyway, indeed self-driving cars can be disruptive for long-distance travel, also in Europe.

Suppose you are traveling between two small towns that are hundreds or thousands of km apart. I think the most reasonable model would be self-driving car from town A to nearest high-speed rail station, high-speed rail to station close to town B, and then self-driving car to town B.

Rail companies could sell the ticket for the whole thing, and owning a car for long-distance travel would make no sense.